In Aseprite, it’s possible to use the Spacekey as a modifier/combo key. This absolutely invaluable and opens up a ton of additional keybind possibilities. For example, I used Space + WASD to navigate layers and frames. W and S to go up/down a layer and A and D to change frames. There’s obviously many more uses and possibilities that open up.
As far as I can tell, this isn’t implemented but I could be wrong.